2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W738587
    Threo-dihydrobupropion-d9 hydrochloride
    rac-threo-Dihydro Bupropion Hydrochloride-d9 is the deuterium labeled Threo-dihydrobupropion hydrochloride (HY-131479). Threo-dihydrobupropion hydrochloride is a primary metabolite of Bupropion. Threo-dihydrobupropion hydrochloride can be used for the research of the depression, behavioral, and biochemistry.
    Threo-dihydrobupropion-d<sub>9</sub> hydrochloride
  • HY-182264
    Masoprocol tetrapivalate
    Masoprocol tetrapivalate (Nordihydroguaiaretic acid tetrapivalate) is a catecholic butane metabolite and also a tyrosine kinase activity inhibitor of IGF-1R and EGFR. Masoprocol tetrapivalate regulates tyrosine kinase signaling pathways associated with cell proliferation. Masoprocol tetrapivalate can be used in the research of proliferative diseases, including malignant, precancerous or benign cancers, and solid tumors.
    Masoprocol tetrapivalate
  • HY-172540
    cyclo-Cannabigerol
    cyclo-Cannabigerol (cyclo-CBG) is the major metabolite of Cannabigerol generated by cytochrome P450. Cyclo-Cannabigerol has weak anti-inflammatory activity.
    cyclo-Cannabigerol
  • HY-123006
    Aszonalenin
    Aszonalenin is a metabolite of Aspergillus zonatus.
    Aszonalenin
  • HY-137208
    Chondroitin disaccharide Δdi-0S sodium
    Chondroitin disaccharide Δdi-0S sodium is an unsaturated disaccharide produced by the degradation of Chondroitin sulfate (HY-B2162). Chondroitin disaccharide Δdi-0S sodium produces fluorescent pyridylamino derivative with 2-aminopyridine, which can be used in studies about the metabolic pathway of Chondroitin sulfate and related disease mechanisms.
    Chondroitin disaccharide Δdi-0S sodium
  • HY-W701262
    2-(Benzhydrylsulfinyl)acetic acid-d10
    2-(Benzhydrylsulfinyl)acetic acid-d10 (Modafinil acid-d10) is the deuterium labeled 2-(Benzhydrylsulfinyl)acetic acid (HY-W103882). 2-Benzhydrylsulfinylacetic acid (Modafinil acid) is the metabolite of modafinil.
    2-(Benzhydrylsulfinyl)acetic acid-d<sub>10</sub>
  • HY-W706737
    N-Deschlorobenzoyl indomethacin-d3
    N-Deschlorobenzoyl indomethacin-d3 is the deuterium labeled N-Deschlorobenzoyl indomethacin (HY-W008567). N-Deschlorobenzoyl indomethacin (Compound 18), the primary metabolite of indomethacin (HY-14397), lacks the N-p-chlorobenzoyl group in its structure. Consequently, N-Deschlorobenzoyl indomethacin loses inhibitory activity against AKR1C2 and AKR1C3 (AKR1C2 IC50 =100 μM, AKR1C3 IC50 >100 μM), exhibiting no selectivity.
    N-Deschlorobenzoyl indomethacin-d<sub>3</sub>
  • HY-118517
    α-Hydroxytamoxifen
    α-Hydroxytamoxifen is a metabolite of tamoxifen, reacts with DNA in the absence of metabolizing enzymes, and causes formation of DNA adducts.
    α-Hydroxytamoxifen
  • HY-125947R
    4-Epioxytetracycline (Standard)
    4-Epioxytetracycline (Standard) is the analytical standard of 4-Epioxytetracycline. This product is intended for research and analytical applications. 4-Epioxytetracycline, the degradation product of Oxytetracycline (OTC), can be found in swine manure compost and wastewater.
    4-Epioxytetracycline (Standard)
  • HY-W766332
    7-Hydroxy coumarin glucuronide sodium-13C6
    7-Hydroxy coumarin glucuronide sodium-13C6 is the 13C-labeled 7-Hydroxy coumarin glucuronide sodium (HY-120201). 7-Hydroxy coumarin glucuronide sodium is a benzopyrone and a metabolite of 7-hydroxy coumarin.
    7-Hydroxy coumarin glucuronide sodium-<sup>13</sup>C<sub>6</sub>
  • HY-N12842
    2-Deoxokanshone L
    2-Deoxokanshone L is a degradation product of Nardosinone (HY-N0380).
    2-Deoxokanshone L
  • HY-137591
    13,14-Dihydro-15-keto-PGE1
    13,14-Dihydro-15-keto-PGE1 is an inactive metabolite of PGE1. 13, 14-Dihydro-15-Keto-pGE1 inhibited platelet aggregation in ADP-induced human isolated platelet-rich plasma with IC50 14.8 μg/mL.
    13,14-Dihydro-15-keto-PGE1
  • HY-W747043
    Megestrol-d3
    Megestrol-d3 is the deuterium labeled Megestrol (HY-B1834). Megestrol is a synthetic progestin and used for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis.
    Megestrol-d<sub>3</sub>
  • HY-161479
    Melamine/OVA
    Melamine/OVA is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Melamine/OVA
  • HY-135180
    1H-1-Ethyl Candesartan Cilexetil
    1H-1-Ethyl Candesartan Cilexetil is a potential impurity found in bulk preparations of Candesartan Cilexetil (HY-17505).
    1H-1-Ethyl Candesartan Cilexetil
  • HY-145516
    Desmethyl Bosentan
    Desmethyl bosentan is an active metabolite of the endothelin receptor antagonist bosentan (HY-A0013).1 Desmethyl bosentan (25 μM) activates the pregnane X receptor (PXR) in CV-1 monkey kidney cells expressing the human receptor in a reporter assay.
    Desmethyl Bosentan
  • HY-W700684
    N-Didesmethyl Loperamide
    N-Didesmethyl Loperamide is a metabolite of Loperamide; a new and improved PET radiotracer for imaging P-gp function.
    N-Didesmethyl Loperamide
  • HY-131279
    Olmesartan ethyl ester
    Olmesartan ethyl ester (compound 11) is an Olmesartan impurity. Olmesartan (RNH-6270) is an angiotensin II receptor (AT1R) antagonist used to in the high blood pressure study.
    Olmesartan ethyl ester
  • HY-W011245R
    Ranitidine S-oxide (Standard)
    Ranitidine S-oxide (Standard) is the analytical standard of Ranitidine S-oxide. This product is intended for research and analytical applications. Ranitidine S-oxide is the metabolite of Ranitidine (HY-B0693). Ranitidine is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion.
    Ranitidine S-oxide (Standard)
  • HY-N17272
    Cholic acid 3-sulfate
    Cholic acid 3-sulfate is the sulfated metabolite of Cholic acid (HY-N0324), produced by liver enzyme sulfotransferase-2A1. Cholic acid 3-sulfate is less toxic than the parent compound, thus serving as a detoxification pathway for bile acids. Cholic acid 3-sulfate does not have the effect of stimulating intestinal secretion.
    Cholic acid 3-sulfate
Cat. No. Product Name / Synonyms Application Reactivity